Abstract
AbstractThe discussion now turns to how to develop imaging probes via solid-phase synthesis (SPS). It is increasingly recognized that this type of chemistry could one day serve as the main pipeline for probe development because SPS enables regioselective reactions with complicated structures. Further, it eliminates solubility and purification complications, which are often encountered with water-soluble near-infrared dyes. This chapter will cover the physical property of different types of resins and their use in SPS. Sample experiments will be discussed for the development of peptides, peptidomimetics, and dyes. Particularly, this SPS is the critical operation for making FRET (fluorescence resonance energy transfer) probes for imaging proteases.
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