Abstract

Biosensors play a key role in medical diagnostics, and acoustic wave technology such as solidly mounted resonators (SMRs) applied to this field is one of the latest developments with great potential. This study seeks to explore the potential application of SMRs to detect and quantify prostate-specific antigen (PSA) for the screening and diagnosis of prostate cancer. The primary results show promising frequency shift of SMR sensors coated with Polydimethylsiloxane (PDMS) to different liquids. The SMR frequency is 1.082, 1.084 and 1.088 GHz, respectively, to air, deionized water and toluene (liquid) presence. These sensors have great potential as an accurate, low-cost method for measuring PSA and biomarkers for cancer and other diseases.

Highlights

  • Prostate cancer is the second most prevalent cancer in men worldwide

  • The theory behind using Film Bulk Acoustic Resonator (FBAR) sensors as liquid biosensors was demonstrated over a decade ago by Weber et al in 2006

  • These sensors have been used primarily for gas sensing in the Microsensors and Bioelectronics Laboratory (MBL), and liquid testing is the first step in adopting this sensor for liquid biosensing

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Summary

Introduction

Prostate cancer is the second most prevalent cancer in men worldwide. According to the UK cancer research, in the UK male population, 1 in 6 will be diagnosed by prostate cancer [1]. Prostate-specific antigen (PSA) is a biomarker that, when elevated, indicates a greater risk of prostate cancer. There is currently no screening program in place in the United Kingdom to identify patients at risk of prostate cancer [3]. The theory behind using Film Bulk Acoustic Resonator (FBAR) sensors as liquid biosensors was demonstrated over a decade ago by Weber et al in 2006 They highlight the ability of these acoustic sensors to detect changes in the mass of up to 2.3 ng/cm2 [4]

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