Abstract
A static analytic method was employed to measure the solubility of azithromycin in the binary water+1,2-propanediol systems at T=(289.35 to 319.15) K. The modified Apelblat equation, the General Single Model and the Hybrid model were used to correlate the solubility data. The mole fraction solubility of azithromycin increased with increasing temperature and the mole fraction composition of 1,2-propanediol. Compared with the experimental data, the back-calculated values of the three models showed good correlation in all cases. The overall root mean square deviations (ORMSD) of the three models are 2.0788, 2.0451 and 5.9461, respectively. However, the modified Apelblat equation and the General Single model led to more reliable and accurate results than the Hybrid model. The fundamental solubility data and the three models in this work could be applied for related process design of azithromycin. Finally, the dissolution Gibbs energy and enthalpy for azithromycin in various binary mixtures were derived from the Van't Hoff and Krug analysis, which indicated that the process was endothermic and nonspontaneous, and the result well agreed with the analysis of their molecular and intermolecular forces.
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