Solid state self-assembly and morphology of a rigid non-coded γ-amino acid inserted tripeptide

Abstract

Abstract A tripeptide Boc-L-Pro-m-ABA-Aib-OMe was synthesized where meta-aminobenzoic acid (m-ABA), a rigid non-coded γ-amino acid is placed as middle residue. Single crystal X-ray diffraction study indicates that the peptide self-assembles into helical motif through intermolecular hydrogen bonding interaction N–H···O, C–H···O, π···π interaction and van der Waals interaction. HR-TEM image reveals the formation of fibril in the solid state.