Abstract
A solid state complex was formed between the oral sulfonylurea drug gliclazide and beta-cyclodextrin by co-precipitation from a methanol:water co-solvent system. The molar stoichiometry of the complex was determined as 1:2, gliclazide to beta-cyclodextrin, by high-performance liquid chromatography. The complex was examined using differential scanning calorimetry, thermogravimetric analysis, diffuse reflectance infra-red Fourier transform spectroscopy and X-ray diffraction. The results indicate that the molecular structure of the complex involves one molecule of beta-cyclodextrin associating with the benzene ring of the gliclazide molecule and a second beta-cyclodextrin associating with the azabicyclooctyl ring of the gliclazide.
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