Abstract
Thermal decomposition of four isopropyl clodronate sodium salts were interpreted from the TG and DTG curves with help of mass spectrometry. The compounds studied were {[hydroxy(1-methylethoxy)phosphino] dichloromethyl} phosphonic acid trisodium salt or monoisopropyl clodronate trisodium salt (compound 1), {[bis(1-methylethoxy)phosphino]dichloro-methyl}phosphonic acid disodium salt or P,P-diisopropyI clodronate disodium salt (compound 2), (dichloromethylene)bisphosphonic acid P,P'-bis(1-methylethyl) ester disodium salt or P,P'-diisopropyl clodronate disodium salt (compound 3), {[bis(1-methylethoxy)phosphino]dichloro-methyl}phosphonic acid mono(1-methylethyl) ester monosodium salt or triisopropyl clodronate monosodium salt (compound 4)
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