Abstract
The purpose of the present study was to prepare inclusion complex of domperidone with hydroxylpropyl-β-cyclodextrin in order improved the solubility and hence to increase dissolution of domperidone. An effect of concentration of hydroxylpropyl-β-cyclodextrin on the aqueous solubility of domperidone was determined by phase-solubility method. The aqueous solubility of domperidone increased as a function of hydroxylpropyl-β-cyclodextrin concentration, showing AL type diagram. Solid domperidone/hydroxylpropyl-β-cyclodextrin complex was prepared in ratio 1:1 by ultrasonication and kneading method. Solid state inclusion complex was characterized by FTIR, powder X-ray diffraction and differential-scanning calorimetry techniques. FTIR studies showed intactness of drug in complex whereas powder diffraction studies showed that hydroxylpropyl-β-cyclodextrin complex was amorphous. Solubility studies showed that complexation increased domperidone solubility as compared to pure drug in 0.1M hydrochloric acid and distilled water. Drug content confirms that ultrasonication is one of the efficient methods to prepare inclusion complex. Dissolution data of inclusion complexes also indicated that there is 1.4 folds increase in dissolution as compared to pure drug and was observed in case of inclusion complexes prepared by ultrasonication.
Highlights
The purpose of the present study was to prepare inclusion complex of domperidone with hydroxylpropyl-βcyclodextrin in order improved the solubility and to increase dissolution of domperidone
Inclusion complexes have been prepared of HP-β-CD and DPD in solid state
DPD and HP-β-CD (KNHP1) were weighed (1:1 molar ratio) and transferred to a mortar and kneaded for 45 min, using equivolume alcohol-water mixture, sufficient solvent was added to maintain a paste like consistency
Summary
The purpose of the present study was to prepare inclusion complex of domperidone with hydroxylpropyl-βcyclodextrin in order improved the solubility and to increase dissolution of domperidone. DPD and HP-β-CD (KNHP1) were weighed (1:1 molar ratio) and transferred to a mortar and kneaded for 45 min, using equivolume alcohol-water mixture, sufficient solvent was added to maintain a paste like consistency. The percent drug content of each inclusion complex was determined using powder equivalent to 10 mg DPD and was dissolved in 20 ml 0.1M HCl using the mechanical shaker for 20 min.
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