Abstract
Cellular membrane properties are sensitive to pressure, temperature, and dehydration as well as lipid composition, which can affect function through non-specific lipid-protein interactions [1]. Functional lipid rafts in cellular membranes may correspond to detergent-resistant domains due to the presence of cholesterol. Changes in swelling and stiffening of pure lipid bilayers in the liquid-crystalline phase have been observed [2-4] with addition of detergent and cholesterol. Here we show how structure and associated dynamics of mixed-lipid bilayers are affected by osmotic pressure.
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