Abstract
ABSTRACT Mixed-ligand complexes of Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with adenine as primary ligand and 5-bromouracil as secondary ligand were prepared in aqueous ethanol solution at pH of about 7 and subjected to a screening system of Dalton's Lymphoma (DL) tumor cells in vitro for the evaluation of viability, 3H-thymidine incorporation and induction of apoptosis in tumor cells. The isolated complexes were characterized by various physico-chemical methods. Solution studies were performed pH-metrically for the interaction of the above metal ions with adenine and 5-bromouracil separately (binary) and in the presence of each other (ternary) at 25±0.1 °C temperature and a constant ionic strength of 0.1 M NaNO3 in aqueous solution.
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