Abstract
Physicochemical properties and dissolution of Fenofibric acid (FA) solid self-nano emulsifying drug delivery system (solid SNEDDS) were investigated. Kollisolv® MCT 70 (medium-chain triglyceride), Kolliphor® RH 40, and Transcutol® HP as the oil, surfactant, and cosurfactant for SNEDDS formulation. The optimized SNEDDS formulation was solidified into solid SNEDDS using porous carriers (Neusilin® US2 and Aerosil 200), with a ratio of 33% and 50% (w/v) respectively (SS1–SS4). The selected solid SNEDDS formulation of FA (SS1) could increase the dissolution of FA 1.75-fold compared to the pure drug.
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