Abstract
Background: A solid pseudopapillary tumor (SPT) of the pancreas is a rare neoplasm with low malignancy, constituting about 2% of pancreatic tumors, which mainly occurs in young women.Case Presentation: We herein report a case of a small SPT arising from the head of the pancreas in an asymptomatic 50-year-old man. This patient was admitted to our department at Henan Provincial People's Hospital for the evaluation of a pancreatic mass and a pancreatic resection was performed. Histology revealed the lesion to be an SPT of the pancreas, with the characteristic pseudopapilla formation, central degeneration, and capsule formation. The tumor was positive for vimentin, CD10, α1-antichymotrypsin, α1-antitrypsin, β-catenin, neuron-specific enolase, synaptophysin, and progesterone receptor.Conclusion: We diagnosed an SPT in the patient based on these histological findings and immunophenotype.
Highlights
Solid pseudopapillary tumors (SPTs) of the pancreas, first described by Virginia Frantz in 1959,1 are an uncommon but distinct pancreatic neoplasm with lowgrade malignant potential, accounting for 0.2–2.7% of all pancreatic tumors.[2]
In 1996, the World Health Organization renamed it as solid pseudopapillary tumor (SPT), which has a variety of names including solid and cystic tumor, Frantz tumor, papillary epithelial neoplasm, solid-cystic papillary epithelial tumor, and papillary cystic tumor
We report a case of a 50-year-old man who presented with a small SPT in the area of the pancreatic head with clinical information, computed tomography (CT) findings, pathological features, and a literature review
Summary
Solid pseudopapillary tumors (SPTs) of the pancreas, first described by Virginia Frantz in 1959,1 are an uncommon but distinct pancreatic neoplasm with lowgrade malignant potential, accounting for 0.2–2.7% of all pancreatic tumors.[2]. Pathological examination reveals that SPTs are usually a large, encapsulated mass composed of a mixture of cystic, solid, and hemorrhagic components. Both a capsule and intratumoral hemorrhage are important clues to the diagnosis because these features are rarely found in other pancreatic neoplasms. The tumor cells were positive for vimentin, CD10, a-1-antichymotrypsin (AACT), a-1-antitrypsin (AAT), b-catenin, neuron-specific enolase (NSE), progesterone receptor (PR), and synaptophysin (Syn) in approximately 30% of the cells, whereas cells were positive for Ki-67 antigen (a proliferation marker) less than 1% of the neoplastic cells (Fig. 4) These findings helped to establish a diagnosis of SPT of the pancreas. The patient is still alive at the time of publication
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