Solid pseudopapillary neoplasm of the pancreas in pediatric patients: A case report and institutional case series

Abstract

Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor presenting in adolescent and young adult females. A previously healthy 13 year-old female presented to our institution with abdominal pain and emesis. Imaging revealed a pancreatic cystic mass. Endoscopic ultrasound (EUS) with fine needle biopsy suggested SPN. Pathologic evaluation following resection revealed immunohistochemical (IHC) staining positive for β-catenin and α-1-antitrypsin despite extensive necrosis. We discuss this patient as well as our institutional series of SPN of the pancreas, describing the evaluation, management, and histopathology of this rare tumor. • Solid pseudopapillary neoplasm (SPN) of the pancreas is the most common form of pancreatic cancer in children. • Immunohistochemistry may be used to confirm the diagnosis of SPN of the pancreas. • Patients with SPN of the pancreas who undergo complete surgical resection can expect an excellent prognosis.