Solid-Phase Synthesis of Unprotected N-Glycopeptide Building Blocks for SPOT Synthesis of N-linked Glycopeptides.

Abstract

High yields and pure products characterize this efficient synthesis of unprotected N-glycopeptide building blocks on the solid phase (see scheme). These can subsequently be used in the synthesis of N-glycopeptide libraries on a continuous surface. Fmoc = 9-fluorenylmethoxycarbonyl, Pfp = pentafluorophenyl.