Solid phase synthesis of peptides containing novel L-phenylalanine derivatives substituted with vicinal tricarbonyl moieties

Abstract

Novel Fmoc-L-phenylalanine derivatives 1 substituted with masked vicinal tricarbonyl moieties were incorporated into a peptide sequence using solid phase peptide chemistry. The oxidative cleavage of the peptide phophoranylidene intermediates to the trioxo compounds 3 was achieved in solution and on solid support with Oxone ® as oxidant.