Solid-phase synthesis of “head-to-tail” cyclic peptides via lysine side-chain anchoring

Abstract

The N,N′-disuccinimidyl carbonate (DSC) has been successfully used for the efficient conversion of conventional hydroxymethyl resins into active carbonate resins, which are suitable for the incorporation of protected amino acids via an amino function, allowing the preparation of “head-to-tail” cyclic lysine containing peptides.