Abstract
A home-made reactor possessing functions including reaction,blending,bubbling,protecting with N2 and filtration was fabricated.The effects of the type of resin,solvent,coupling reagent and reaction time on the yield of cyclic eptifibatide were investigated.The results showed the overall yield was up to 86.6%,using Rink Amide AM resin as solid supporter,HBTU/HOBt/DIEA as the coupling reagent,DMF as the solvent and reaction 2 hours in the reactor.The purity of the product as revealed by HPLC could reach 98%.
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