Abstract
A new solid phase method for automated synthesis of peptide-oligodeoxynucleotide conjugates is described. The conjugates were synthesized on a high-loaded polyethyleneglycol-polystyrene (HLP) support by first linking a branched modifier to the support, then using Fmoc chemistry for peptide coupling, and phosphoramidite chemistry for deoxynucleotide coupling. The peptide is designed to act as an antagonist to insulin-like growth factor 1 receptor (IGF1-R).
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