Abstract

AbstractTo implement the solid phase synthesis of 4″‐epi‐methylamino‐4″‐deoxyavermectin B1 benzoate, tert‐butyl‐ dimethylsilylchloride was chosen for the first solution synthesis. Then a novel silyl chloride resin 1, achieved from hydroxymethyl polystyrene resin and dimethyldichlorosilane, was used successfully for the attachment of avermectin B1 2. Through oxidation, amination formation, cleavage, and benzoate formation, resin bounded avermectin B1 9 gave 4″‐epi‐methylamino‐4″‐deoxyavermectin B1 benzoate 6.

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