Solid Phase Synthesis of 4,5-disubstituted 1,2,4-triazol-3-one Derivatives from resin-bound Acylhydrazines

Abstract

A new strategy for solid-phase synthesis of 4,5-disubstituted 2,4-dihydro-3 H-1,2,4-triazol-3-ones has been developed. The 4-substituted 5-(4-hydroxyphenyl)-1,2,4-triazol-3-one derivatives were synthesised from resin-bound acylhydrazines in several steps, in good overall yields and purity.