Abstract
The solid phase synthesis of 1,3,4,7-Tetrasubstituted Perhydro-1,4-diazepine-2,5-diones is described. Starting from the resin-bound tBu ester of aspartic acid and employing reductive alkylation and amide formation, 40 diazepines have been synthesized in good yield and high purity. The general nature of this approach permits not only large numbers of individual diazepines to be prepared, but also combinatorial libraries.
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