Solid phase peptide synthesis of mucin glycopeptides

Abstract

The synthesis of the new glycosylamino acid building block N α-Fmoc-Thr(Ac 4-β-D-Galp)-(1→3)-(Ac 2-α-D-GalpN 3)-OPfp 3 and its use in a solid phase synthesis of triple glycosylated peptides from human intestinal mucin is described. The azide reduction was performed with thioacetic acid on the polymere bound glycopeptides.