Abstract
(1) Background: ZIF-67 is one of the most intriguing metal–organic frameworks already applied in liquid adsorption. To increase its adsorption performance, dual ionic liquids were immobilized on ZIF-67 in this research; (2) Methods: The obtained sorbent was used to adsorb aristolochic acid I (AAI) in standard solutions. Then, the sorbent was applied in solid-phase extraction to remove AAI from Fibraurea Recisa Pierre extracted solution. (3) Results: By analyzing the adsorption models, the highest adsorption capacity of immobilized sorbent (50.9 mg/g) was obtained at 25 °C within 120 min. In the SPE process, 0.02 mg of AAI was removed per gram of herbal plant, the adequate recoveries were in the range of 96.2–100.0%, and RSDs were 3.5–4.0%; (4) Conclusions: The provided experimental data revealed that ZIF-67@EIM-MIM was an excellent potential sorbent to adsorb and remove AAI from herbal plant extract, and the successful separation indicated that this sorbent could be an ideal material for the pretreatment of herbal plants containing AAI.
Highlights
IntroductionBioactive compounds from herbal medicines are widely used; not all bioactive compounds in natural plants are safe
Plant Using Dual Ionic Liquid-Bioactive compounds from herbal medicines are widely used; not all bioactive compounds in natural plants are safe
In the SPE process, 0.02 mg of aristolochic acid I (AAI) was removed per gram of herbal plant, the adequate recoveries were in the range of 96.2–100.0%, and relative standard deviations (RSDs) were 3.5–4.0%; (4) Conclusions: The provided experimental data revealed that ZIF-67@EIM-MIM was an excellent potential sorbent to adsorb and remove AAI from herbal plant extract, and the successful separation indicated that this sorbent could be an ideal material for the pretreatment of herbal plants containing AAI
Summary
Bioactive compounds from herbal medicines are widely used; not all bioactive compounds in natural plants are safe. Aristolochia and related plants are frequently used to cure diseases of the respiratory system in Asian countries. Aristolochic acid I (AAI), a quite harmful compound in genus of Aristolochia plants, can cause a variety of kidney diseases and even cancer in humans [1]. Drug Administration issued a safety alert that dietary supplements or other botanicalcontaining products containing AAI have been associated with nephropathy. To detect 289 samples and the results demonstrated that most representatives from the Aristolochiaceae family contain toxic AAs [2]. The AAI as a hazardous compound should be removed before using the herbal plants
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