Abstract
AbstractViedma ripening is an emerging method for the solid‐phase deracemization of mixtures of enantiomers. Up to now, the scope of the method has remained limited to molecules with a single stereocenter. We show here that this method can be extended to obtain a single enantiomer from a mixture of stereoisomers with two different stereocenters. In addition, we show that by using tailor‐made chiral additives, the conversion time can be reduced by a factor of 100.
Highlights
Viedma ripening is an emerging method for the solid-phase deracemization of mixtures of enantiomers
We show here that this method can be extended to obtain a single enantiomer from a mixture of stereoisomers with two different stereocenters
Deracemization methods can be used, in which the unwanted enantiomer is converted into the desired product
Summary
Viedma ripening is an emerging method for the solid-phase deracemization of mixtures of enantiomers. We show here that this method can be extended to obtain a single enantiomer from a mixture of stereoisomers with two different stereocenters. Only molecules with a single stereocenter have been deracemized using Viedma ripening.
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