Abstract
The resin-bound dipropargylamine 3 was prepared by treatment of commercially available trityl chloride resin 1 with dipropargylamine 2 using N,N-diisopropylethylamine as a base. The microwave-assisted iridium-catalyzed [2+2+2] cycloaddition of 3 with several alkynes 4, followed by TFA cleavage and catch-release purification with basic alumina of resin-bound intermediates 5, gave the corresponding salt-free isoindoline derivatives 6 in 50-70% yields.
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