Solid -papillary carcinoma of the breast, an analysis of 44 cases

Abstract

Objective To investigate the clinicopathological features of solid papillary carcinoma of the breast. Methods A retrospective study was performed to analyze the clinical and histopathologic manifestations in 44 cases of SPC in Peking University People′s Hospital from 2013.7 to 2017. 10. Results All the patients were female and mean age was 66.5 years. 17 cases complained of nipple discharge and 27 cases had breast mass .Pathologically tumors were of solid-papillary growth pattern. The tumor cells were polygonal or oval with mucin production and neuroendocrine differentiation. 22 cases were associated with invasive carcinoma, among which 15 cases were non-special invasive carcinomas. 7 cases were mucinous carcinoma.Six cases underwent modified radical mastectomy and axillary lymph nodes excision with two metastasis in an axillary lymph node.38 cases underwent breast conserving surgery or mastectomy. There were no local recurrence or distant metastasis during the follow-up periods of 12-48 months. Conclusion Solid papillary carcinoma of breast is a rare pathology type with predilection in older women. The postoperative prognosis is fair. Key words: Breast neoplasms; Pathology, clinical; Immunohistochemistry; Prognosis