Abstract
In this work, the solubility of carbamazepine–succinic acid cocrystals in ethanol and acetone were measured at (298.15 and 308.15) K at atmospheric pressure. The solubility product (Ksp) which reflects the strength of cocrystal solid-state interactions of carbamazepine (CBZ) and succinic acid (SUC) relative to interactions with the solvent was determined. The solubility data show that significant complexation occurs in some solutions, and the relevant constants are derived. The ternary phase diagrams for the system of CBZ-SUC-ethanol or acetone at (298.15 and 308.15) K, which can provide the theoretical basis for crystallization processes, are presented.
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