Abstract
Solubility of (R)-(-)-phenylephrine hydrochloride (R-PEHC) in ten pure solvents including methanol (MtOH), ethanol (EtOH), n-propanol (NPrOH), iso-propanol (IPrOH), 2-methoxyethanol, 2-ethoxyethanol, 2-propoxyethanol, 2-butoxyethanol, N-methyl pyrrolidone (NMP) and N,N-dimethylformamide (DMF) was determined by using a laser monitoring technique in the range of 278.15 K to 323.15 K under 0.1 MPa. Solubility of R-PEHC increases with the increment of temperature. The solvent effect on R-PEHC solubility was investigated by the linear solvation energy relationships concept (Kamlet-Taft parameters). The interaction energy (Einter) between R-PEHC and selected solvents was calculated by molecular simulation to explain the solubility behavior. Experimental solubility was correlated by five activity coefficient models including the Two-Suffix Margules model, Wilson model, NRTL model, NRTL-SAC model and uniquac model. Five models can fit experimental solubility values well. Furthermore, thermodynamic properties of solutions of R-PEHC in selected solvents were investigated by the van’t Hoff equation.
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