Abstract
Solid-liquid equilibrium data of erythromycin thiocyanate dihydrate in four mono-solvents (methanol, ethanol, propan-1-ol and propan-2-ol) and three organic+water solvent mixtures (acetonitrile+water, acetone+water and ethanol+water) were determined by a gravimetric method under atmospheric pressure. The effects of content of organic solvents and temperature on the solubility were investigated and discussed. It was found that the content of organic solvents can significantly affect the solubility of erythromycin thiocyanate dihydrate. The modified Apelblat equation and NRTL model were applied to correlate the solubility data in mono-solvents. The GSM, two modified Jouyban-Acree models (the Van't-JA equation and the Apel-JA equation) and NRTL model were used to correlate the experimental data in three binary solvents systems. Computational results indicated that the AIC (Akaike's Information Criterion) values of two Jouyban-Acree models and NRTL model were lower than that of GSM in binary solvents mixtures, which means that the former three models are better for correlating the experimental solubility data. In addition, the mixing thermodynamic properties of erythromycin thiocyanate dihydrate in different solvents were also calculated based on the experimental solubility data and the NRTL model.
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