Abstract
The objective of this work is to obtain the solubility, correlation equation parameters and dissolution thermodynamic properties for N,2,3-trimethyl-2-isopropylbutamide in different solvents, which is essential for its purification and further crystal morphology optimization. By using a static gravimetric method, the solubility of N,2,3-trimethyl-2-isopropylbutamide in seventeen pure solvents (methanol, ethanol, acetone, ethyl acetate, dichloromethane, n-hexane, isooctane, acetonitrile, n-propanol, n-butanol, cyclohexane, isopropanol, n-octanol, cyclohexanone, toluene, 1,2-dichlorobenzene and n-pentanol) was measured over temperature range from 273.15 K to 319.15 K under atmosphere pressure. The results indicated that the mole fraction solubility increased with the rising temperature in all solvents. Besides, the experimental solubility was correlated with the modified Apelblat equation, van't Hoff equation, λh equation, non-random two-liquid (NRTL) equation and Wilson equation. Good agreements were found between the experimental data and above models fitted values, especially the modified Apelblat equation provided the best fitting results. Finally, the dissolution thermodynamic parameters, Gibbs energy (△disG), molar enthalpy (△disH) and molar entropy (△disS) were calculated based on the experimental data and the Wilson model.
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