SOLID LIPID NANOPARTICLES (SLNs) AS NANO DRUG DELIVERY CARRIERS: PREPARATION, CHARACTERIZATION AND APPLICATION

Mona Qushawy,Ali Nasr

doi:10.22159/ijap.2020v12i1.35312

Abstract

Over the last few years, there has been a significant consideration of solid lipid nanoparticles (SLNs) as an alternative method to other colloidal dispersion methods for drug delivery. Special consideration has been given to the use of SLNs as a drug carrier in recent years. SLNs are aqueous dispersions in which the colloidal particles consist of solid lipids that are biodegradable. As a result of their physical stability, the protection of the entrapped drug from decomposition, the provision of controlled drug release, and the exceptional acceptability, SLNs have several advantages over other drug carriers. This article focuses on the techniques of SLNs preparation and characterization, the effect of formulation variables on SLNs properties, the routes of administration, and the pharmaceutical applications. The data used for this review was collected by searching on Google Scholar and PubMed using the following keywords during the period from 2010 to date.

Highlights

Novel drug delivery systems are rapidly developing as a result of the success achieved in disciplines such as biomedical engineering, biotechnology, and nanotechnology
Several studies have reported the use of a solid lipid in the preparation of solid lipid nanoparticles (SLNs) instead of a liquid lipid, which allows the slow digestion of the nanoparticles resulting in the continued release of the entrapped drugs
Based on the previous study, it was found that when the volatile oil extracted from Artemisia arborescent L is incorporated into SLNS, it decreases the rapid evaporation compared to its incorporation into emulsions

Summary

INTRODUCTION

Novel drug delivery systems are rapidly developing as a result of the success achieved in disciplines such as biomedical engineering, biotechnology, and nanotechnology. When the concentration of the active ingredient in the lipid melt is high and comparatively near saturation, the core model is developed In this method, cooling Nano-emulsion leads to the precipitation of the drug due to super saturation at low temperatures. Karami et al prepared Superoxide dismutaseloaded SLNs using the cold homogenization method [21] This technique is one of the techniques which are used to produce SLNs. This technique is one of the techniques which are used to produce SLNs In this technique, the aqueous phase containing a large quantity of surfactant is dispersed with the lipid phase, as shown in fig. The inability to produce nanoparticles with a narrow size distribution, thereby giving rise to instability during storage, is considered as a drawback for this technique This method, unlike the hot and cold homogenization, makes use of simple instruments that are readily available almost in all laboratories [23, 24]. The selection of the technique depends on the chemical shifting balances and the sensitivity to molecular flexibility to provide data about the physicochemical state of the constituent inside the nanoparticles [10]

Acoustic methods

Methods

CONCLUSION

Findings