SOLID LIPID NANOPARTICLES OF GABAPENTIN FOR PARTIAL SEIZURES

Abstract

The goal of this research was to create a stable formulation of gabapentin solid lipid nanoparticles which would allow it to pass across the blood-brain barrier more easily. They were prepared by solvent evaporation method. In the present investigation, beeswax and carnauba wax were used as solid lipids, egg lecithin was used as a surfactant and Tween 80 was used as a co-surfactant. Nine formulations were formulated using different concentrations of solid lipid and surfactant. The prepared formulations were evaluated for various tests. The results shown that F6 formulation, containing higher concentration of egg lecithin, was a better formulation as percentage drug content was 97.57±0.62%, entrapment efficiency was 95.95±0.07% and in vitro release of gabapentin was 97.18±1.02% at the end of 12 h. After in vivo testing, it was observed that animals treated with gabapentin loaded solid lipid nanoparticles had seizures that appeared later than animals treated with traditional gabapentin formulations. Hence it was concluded that solid lipid nanoparticles is a promising drug delivery system to achieve increased permeability through blood brain barrier.