Abstract
Transdermal administration of drugs has advantages over conventional oral administration or administration using injection equipment. The route of administration reduces the opportunity for drug evacuation before systemic circulation, and enables long‐lasting drug administration at a modest body concentration. In addition, the skin is an attractive route for vaccination, because there are many immune cells in the skin. Recently, solid‐in‐oil nanodisperison (S/O) technique has demonstrated to deliver cosmetic and pharmaceutical bioactives efficiently through the skin. S/O nanodispersions are nanosized drug carriers designed to overcome the skin barrier. This review discusses the rationale for preparation of efficient and stable S/O nanodispersions, as well as application examples in cosmetic and pharmaceutical materials including vaccines. Drug administration using a patch is user‐friendly, and may improve patient compliance. The technique is a potent transcutaneous immunization method without needles.
Highlights
Transdermal drug delivery is a technique to administer drugs via the skin for systemic distribution as well as for local distributions [1,2,3]
We briefly describe the advantages and disadvantages of nanosized carriers including the solid-in-oil nanodisperison (S/O) nanodispersion systems (Table 1), to overcome the skin barrier by simple application of a patch, with a focus on transcutaneous vaccination using the immune system in the skin
These results indicate that the S/O nanodispersion system is highly recommended for delivery of hydrophilic molecules such as proteins and peptides
Summary
Transdermal drug delivery is a technique to administer drugs via the skin for systemic distribution as well as for local distributions [1,2,3]. Advantageous application area Drug delivery efficiencies (cumulative amounts in the skin)a). A)Cumulative amounts of drugs in the Yucatan micropig skins after application of the S/O nanodispersion systems for 24 h (APM) or 48 h (DFNa and insulin) were examined using Frantz-type diffusion cells. With either type of enhancer, crossing the stratum corneum, the outermost layer in the skin, is the key to efficient transdermal drug delivery [25]. We briefly describe the advantages and disadvantages of nanosized carriers including the S/O nanodispersion systems (Table 1), to overcome the skin barrier by simple application of a patch, with a focus on transcutaneous vaccination using the immune system in the skin
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