Solid form of indapamide recrystallized from acetonitrile/diethyl ether solvent mixture

Abstract

Indapamide (IDP) is a non-thiazide sulphonamide diuretic drug generally used for the treatment of essential hypertension. The aim of this work was to obtain and to characterize new solid forms of IDP. In this respect, the recrystallization of IDP from different solvent or solvent mixtures was carried out. Thermoanalytical techniques (differential scanning calorimetry (DSC) and thermogravimetry (TG)), X-ray powder diffraction (XRPD), Fourier transform infrared spectroscopy (FTIR), solid state nuclear magnetic resonance (NMR) spectroscopy and scanning electron microscopy (SEM) were used for structural characterization of the new obtained solid forms. Based on the results of these techniques we can conclude that IDP recrystallized from acetonitrile+ diethyl ether solvent mixture presents a different structure and physical properties as compared with the starting IDP.