Abstract
Presently only few percent of drugs having high aqueous solubility, Number of drugs are belonging to biopharmaceutical classification system class II that means possessing poor aqueous solubility eventually results in low level of drug in systemic circulation. To overcome this problem, various strategies have been come out into notion such as self emulsifying drug delivery system solid dispersions, use of surface active agents, complex formation. Solid dispersions is found to be promising approach to increase bioavailability by use of various polymers. This review focuses on the mechanism of drug release from solid dispersion with its method of preparation and applications.
 Key words: dissolution, particle size, solid dispersion
Highlights
Enhancement of bioavailability of hydrophobic drugs is one of the major challenges in drug development; solid dispersion is one of the useful methods for the dispersion of the drug into an inert, hydrophilic polymer matrix[1]
A large number of studies have been published but the mechanisms underpinning the observed enhancement of the rate of drug release are not yet understood 2.The use of solid dispersions as an effective source of improving the dissolution rate of poorly soluble drugs has been well studied and demonstrated
The poorly water soluble drugs are characterised by insufficient bioavailability and absorption in the gastrointestinal tract[3]
Summary
Enhancement of bioavailability of hydrophobic drugs is one of the major challenges in drug development; solid dispersion is one of the useful methods for the dispersion of the drug into an inert, hydrophilic polymer matrix[1]. It has been shown by Sekiguchi and Obi in 1961 that the formulation of eutectic mixtures improved the rate of drug release which in turn increases the bioavailability of poorly water soluble drugs. Solid dispersions systems developed by Levy (1963) and Kanig (1964), who made solid solutions by using molecular dispersions instead of using eutectic mixtures, with mannitol as carrier These improvements were due to faster carrier dissolution, releasing particles of drug[7, 8]. In high polymer loading there is insufficient drug to support the drug controlling layer formed at the dissolving surface This causes the drug to disperse within the polymer resulting in a carrier-controlled drug release process. Extensive work is required in order to fully understand the association of the carrier and drug in dispersion[20, 21, 22]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
