Abstract
Herein, we present for the first time a novel potentiometric sensor based on the stimulus-responsive molecularly imprinted polymer (MIP) as a selective receptor for neutral dopamine determination. This smart receptor can change its capabilities to recognize according to external environmental stimuli. Therefore, MIP-binding sites can be regenerated in the polymeric membrane by stimulating with stimulus after each measurement. Based on this effect, reversible detection of the analyte via potentiometric transduction can be achieved. MIPs based on 4-vinylphenylboronic acid as the functional monomer were prepared as the selective receptor. This monomer can successfully bind to dopamine via covalent binding and forming a five- or six-membered cyclic ester in a weakly alkaline aqueous solution. In acidic medium, the produced ester dissociates and regenerates new binding sites in the polymeric membrane. The proposed smart sensor exhibited fast response and good sensitivity towards dopamine with a limit of detection 0.15 µM over the linear range 0.2–10 µM. The selectivity pattern of the proposed ISEs was also evaluated and revealed an enhanced selectivity towards dopamine over several phenolic compounds. Constant-current chronopotentiometry is used for evaluating the short-term potential stability of the proposed ISEs. The obtained results confirm that the stimulus-responsive MIPs provide an attractive way towards reversible MIP-based electrochemical sensors designation.
Highlights
Dopamine is one of the most critical neurotransmitters belonging to the catecholamine and phenethylamine families
The results showed a linear relationship between the measured potential and the concentration of neutral dopamine in the range 0.2 to 10 μM and a detection limit of 0.15 μM (3σ)
A reliable, robust and cost-effective solid-contact Ion-selective electrodes (ISEs) based on man-tailored mimics for the potentiometric transduction of neutral dopamine was presented
Summary
Dopamine is one of the most critical neurotransmitters belonging to the catecholamine and phenethylamine families. It can bind a wide range of analytes with high affinity and enhanced selectivity similar to those enzymes and antibodies All these features make this type of ion receptors suitable for their use as promising ionophores in manufacturing ISEs. A stimulus can influence on these responsive-polymers and make them have the ability to alter some of their properties, such as molecular structures, surface properties and degeneration behaviors. The sensors were successfully applied for dopamine determination in human serum and pharmaceutical formulations Using these smart MIPs in conjunction with potentiometric sensors could provide an effective way to achieve selective, sensitive and reversible detection of dopamine
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
