Abstract
BackgroundThe computed tomography (CT) characteristic of ground glass opacity (GGO) were shown to be associated with clinical significance in lung adenocarcinoma. We evaluated the prognostic value of the solid component ratio of GGO IA invasive lung adenocarcinoma.MethodsWe retrospectively analyzed the records of GGO IA patients who received surgical resection from April 2012 to December 2015. The solid component ratio was calculated based on thin-slice CT scans. Baseline features were compared stratified by the ratio. Cox proportional hazard models and survival analyses were adopted to explore potential prognostic value regarding overall survival (OS) and disease-free survival (DFS).ResultsFour hundred fifteen patients were included. The higher ratio was significantly associated with larger tumor diameter, pathological subtypes and choice of surgical type. There was a significantly worse DFS with a > 50% ratio. The subgroups of 0% and ≤ 50% ratio showed close survival curves of DFS. Similar trends were observed in OS. Multivariate analyses revealed that the ratio was a significant predictor for DFS, but not for OS. No significant prognostic difference was observed between lobectomy and limited resections.ConclusionA higher solid component ratio may help to predict a significantly worse prognosis of GGO IA lung adenocarcinoma.
Highlights
Lung adenocarcinoma is the most common histological subtype of non-small cell lung cancer with high morbidity and mortality worldwide, which presents an increasing incidence rate [1]
Synopsis The higher ratio of solid component was significantly associated with clinicopathological features of ground glass opacity (GGO) patients with IA stage disease, such as tumor diameter and pathological subtype
In 2011, the International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society proposed a new multidisciplinary classification system for lung adenocarcinoma, which were mainly composed of adenocarcinoma in situ, Sun et al Cancer Imaging (2020) 20:87 minimally invasive, and invasive adenocarcinoma [2]
Summary
Lung adenocarcinoma is the most common histological subtype of non-small cell lung cancer with high morbidity and mortality worldwide, which presents an increasing incidence rate [1]. Stage lung adenocarcinoma is often detected as showing ground glass opacity (GGO) in thoracic thin-slice computed tomography (CT). The histology subtype and tumor invasion status under the new classification system have significant prognostic impact in lung adenocarcinoma [3,4,5]. Our previous work indicated that the CT characteristics of GGO were significantly correlated with histological subtype and gene mutation rate in lung adenocarcinoma [6]. Further studies are required to investigate the potential role of the solid components in different subgroups regarding stage and invasion status in GGO-featured lung adenocarcinoma. The computed tomography (CT) characteristic of ground glass opacity (GGO) were shown to be associated with clinical significance in lung adenocarcinoma. We evaluated the prognostic value of the solid component ratio of GGO IA invasive lung adenocarcinoma
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