“SOLID AS SOLVENT”- NOVEL SPECTROPHOTOMETRIC ANALYTICAL TECHNIQUE FOR ORNIDAZOLE TABLETS USING SOLIDS (EUTECTIC LIQUID OF PHENOL AND NIACINAMIDE) AS SOLUBILIZING AGENTS (MIXED SOLVENCY CONCEPT)

Abstract

The present investigation is an attempt to show that solids can also be wisely used to act as solvent precluding the use of organic solvents. Present study describes the application of solvent character of eutectic liquid consisting of phenol and niacinamide in 25:10 ratio (PNM 2510) on weight basis for spectrophotometric estimation of ornidazole tablets. Proposed method is novel, rapid, free from toxicity of organic solvent, accurate and reproducible. Recovery studies and statistical data proved the accuracy, reproducibility and precision of the proposed method.