Solid acid catalyst TS-1 zeolite-assisted solvent-free one-pot synthesis of poly-substituted 2,4,6-triaryl-pyridines

Abstract

A new method is described for one-pot solvent-free synthesis of 2,4,6-triaryl pyridines in the presence of a solid acid catalyst, titanium silicate (TS-1) via cyclocondensation of acetophenone, aryl aldehyde and ammonium acetate. The present method illustrates several advantages, such as eco-friendly reaction conditions, simplicity, short reaction time (3 h), easy separation of catalyst and high yields of the products (85–93%). Furthermore, the TS-1 catalyst was reused for four catalytic cycles with consistent catalytic activity.