Abstract
In this work, new phenol-based materials have been synthesized by the sol-gel method, in which different amounts of the phenolic antioxidant chlorogenic acid (CGA) (from 5 wt % to 20 wt %) were embedded in two different silica matrices: pure silica and silica-based hybrids materials, containing 50 wt % of polyethylene glycol (PEG). The incorporation of CGA in different sol-gel matrices might protect them from degradation, which could cause the loss of their properties. The two series of materials were chemically characterized by Fourier transform infrared (FTIR) spectroscopy. In addition, the thermal behavior of both series of materials containing CGA was studied by thermogravimetry under both air and inert N2 flowing gas atmosphere. The bioactivity was evaluated by soaking the synthesized hybrids in a simulated body fluid, showing that the bioactivity of the silica matrix is not modified by the presence of PEG and CGA.
Highlights
Biomaterial implants are clinically used in a variety of applications, and their interaction with cells or tissue is important for the patient health and quality of life
The bioactivity was evaluated by soaking the synthesized hybrids in a simulated body fluid, showing that the bioactivity of the silica matrix is not modified by the presence of polyethylene glycol (PEG) and chlorogenic acid (CGA)
Band and the peak at 580 cm−1 at a lower wavenumber, may be due to the formation of hydrogen bonds [45] between the –OH groups of the inorganic phases and ethereal oxygen atoms (H-bond donors) or terminal –OH in the PEG chains. These results suggest that the presence of chlorogenic acid does not change the structure and interactions of SiO2 /PEG hybrid materials
Summary
Biomaterial implants are clinically used in a variety of applications, and their interaction with cells or tissue is important for the patient health and quality of life. They should act as artificial replacements, since the primary requirement of any material is its biocompatibility inside the human body [1]. The production of high amounts of reactive oxygen species (ROS) and H2 O2 occurs These inflammatory events of implant integration are necessary at the early stages for efficient wound healing, but a persistent oxidative stress might be the main cause of failure in orthopedic implants [5]. Orally administered drugs have typically been used to control
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