Abstract
Solanum trilobatum is a widely used plant in the Indian indigenous systems of medicine. It is mainly used in the treatment of respiratory diseases like bronchial asthma. In our present study, we report that the aqueous and alcoholic extracts of S. trilobatum exhibited inhibition of mast cell degranulation. Further, aqueous and alcoholic extracts of S. trilobatum significantly decreased the release of IL1α and increased the release of IL8 from the cultured keratinocytes. Oral administration of the aqueous and alcoholic extracts of S. trilobatum stabilized mast cells in experimental rats.
Highlights
Solanum trilobatum belongs to the family Solanaceae, which is commonly known as Alarka in Sanskrit
The use of synthetic antihistamines to control atopic allergy over a prolonged period of time could lead to potential side effects, and the relief offered by them is Address for correspondence: Dr M
S. trilobatum plant was collected from Chennai, south India, and authenticated by the Department of Plant Biology and Biotechnology, The New College, Chennai
Summary
Solanum trilobatum belongs to the family Solanaceae, which is commonly known as Alarka in Sanskrit. Several reports document the diverse properties of this plant. S. trilobatum possesses antioxidant activity,[1] hepatoprotective activity[2]. Protects against UV-induced damage and radiationinduced toxicity in mice.[3] Aqueous and solvent extracts of S. trilobatum were found to possess anti-inflammatory and antimicrobial properties.[4,5,6]. A safe and effective management of atopy through plant resources has received much attention in recent years. This study was undertaken to evaluate the efficacy of aqueous and solvent extracts of. S. trilobatum in regulating the mast cell degranulation event and inflammatory responses (IL1a and IL8) through in vitro and in vivo studies. The determination of efficacy of these extracts in preventing the disease progression in experimental model was attempted
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