Abstract
The aim of the study was to evaluate the anti-inflammatory activity of the S. paranense crude extract, S. paranense alkaloid fraction, and solanine alkaloid. These samples reduce the croton oil-induced ear edema in a dose-dependent manner and a maximum inhibition of 81%, 98%, and 80% in the doses of 1.0, 0.73, and 0.37 mg/ear, respectively. Moreover, the samples inhibit the MPO activity with an inhibition maximum of 51%, 40%, and 46% in the doses of 1.0, 0.73, and 0.37 mg/ear, respectively. Similar results were found for dexamethasone 0.10 mg/ear (positive control), which showed inhibitions of ear edema and MPO activity of 100% and 65%, respectively. These results found probably are related to the presence of solanine which is present in significant quantity in the alkaloid fraction and others as rutin and rosmarinic, chlorogenic, and gallic acids. These results support the use of S. paranense for the treatment of inflammatory skin disorders.
Highlights
The skin is the first interface between the body and the environment, providing the primary defense against microbial pathogens and injuries through physical, biochemical, and immunological mechanisms [1]
The alkaloid fraction showed a yield of 73% (w/w) in relation to the extract and analysis by high performance liquid chromatography (HPLC) 506±1.75 mg/g of solanine in the S. paranense alkaloid fraction and 371.06 mg/g in the crude extract (Figure 2) were quantified
We assessed the anti-inflammatory activity of the crude extract, alkaloid fraction of S. paranense, and solanine in a croton oil-induced acute skin inflammation model
Summary
The skin is the first interface between the body and the environment, providing the primary defense against microbial pathogens and injuries through physical, biochemical, and immunological mechanisms [1] The regulation of these mechanisms is essential because they are implicated in the pathogenesis of several topical inflammatory disorders [2]. Solanum paranense Dusen is among such species, popularly known as Joa-velame, belonging to genus Solanum (family Solanum) [8], and until the moment, there are no studies related to this species Taking into consideration these facts, the aim of this study was to evaluate the topical antiinflammatory activity of the S. paranense crude extract, S. paranense alkaloid fraction, and the solanine alkaloid on an Evidence-Based Complementary and Alternative Medicine acute model of skin inflammation in mice and relate this activity with its constituent compounds
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