Abstract
This study was conducted to evaluate the topical efficacy of Solanum incanum for the treatment of partial-thickness burn in mice model. Mice were treated with topical ointment of S. incanum three times daily for 14 days. The wound healing was observed through wound contraction and histological parameters. The group treated with S. incanum ointment showed 81% reduction in wound area as compared to negative control where wound area reduced to 22%. The histological analysis further confirmed that ointment favors the tissue regeneration and reepithelization thus heal wound rapidly as com-pared to other groups. In conclusion, S. incanum extract enhances wound healing and tissue regeneration.
Highlights
Burn is known as one of the most destructive forms of injury with a vast spectrum of consequences
The positive group showed similar trend as of S. incanum but, the wound contraction was slightly better in positive group
It can be seen in these photographs that contraction started on 4th day and maximum wound closure was observed on the last day of experiment in S. incanum-treated and positive control group
Summary
Burn is known as one of the most destructive forms of injury with a vast spectrum of consequences. It has been reported that about 1/3rd of all herbal medicines in use are for the treatment of skin disorders and wounds (Mantle et al, 2001). Various plants such as Allium sativum (Farahpour et al, 2017), Aloe vera (Maenthaisong et al, 2007), Carica papaya (Gurung and SkalkoBasnet et al, 2009), Centaurea pterocaula (Ötün and Yücel, 2019), Iris forentina (Mirmalek et al, 2015), Otostegia persica (Ganjali et al, 2013), Pistacia lentiscus (Djerrou et al, 2010) have been investigated for the treatment of burn
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