Abstract
Copper-substituted nickel manganites Ni(1−x)CuxMn2O4 (Ni-TCE-NPs) were produced by co-precipitation route (sol–gel) at room temperature. Ni(1−x)CuxMn2O4-Bio (NCB) NPs were studied by powder X-ray diffraction technique, scanning electron microscopy and Raman spectroscopy. XRD spectra authenticated the copper-doped nickel manganites’ formation with particle size 23–28 nm. A significant decrease in the lattice parameter confirmed the doping of copper ions into the nickel manganites. Microscopy (SEM) was used to estimate the grain size, shape and uniformity, revealing the non-uniform agglomerated polygon and plate-like microstructure. The NCB-NPs showed anticoagulant activity by enhancing the coagulation time of citrated plasma of human beings. NCB-NPs with x = 0.35 and 0.45 have increased clotting time from control 133 ± 4 s to 401 ± 7 s and 3554 ± 80 s, respectively, and others around 134 s. Additionally NCB-NPs with x = 0.35, 0.45 inhibited the platelet aggregation by 80% and 92%, while remaining inhibited with only 30%. NCB-NPs did not show hemolytic activity in RBC cells intimate its non-toxic nature. Finally, NCB-NPs were non-toxic and known to exhibit anti-blood-clotting and antiplatelet activities, which can be used in the field of biomedical applications, especially as antithrombotic agents.
Highlights
Magnetic substances have nano-technological applications in areas such as analytical chemistry, biosensing and nano-medicine
The NPs–blood interaction is inevitable, and this study is about the effect of NCB-NPs on blood-clotting cascade and platelet aggregation
The synthesized NCBNPs were characterized by using PXRD, SEM and Raman techniques
Summary
Magnetic substances have nano-technological applications in areas such as analytical chemistry, biosensing and nano-medicine. There is a potential in the study of NPs’ interaction with the components of the blood clotting system that may be an important part of their safety profile. The physical and chemical properties of the NPs’ surface show various types of interactions with the proteins that may lead to changes in protein conformation, activation or inhibition of blood-coagulation factors. Inspired us to perform the biological study on copper-doped nickel manganites These manganites having a general formula AB2 O4 , in which cations reside at both tetrahedral (A-sites) and octahedral (B sites) showed good NTC thermistor properties, dielectric capabilities, magnetic nature and ease of production, are promising materials for biological investigation [10]. Quite a little information is available from the literature regarding anticoagulant and antiplatelet activities of copper-doped nickel manganite nanoparticles. (NCB-NPs), along with their effect on plasma coagulation and platelet aggregation
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