Abstract
The SOHPIER package implements a novel functionality for "multivariable" differential co-abundance network (DN, hereafter) analyses of microbiome data. It incorporates a regression approach that adjusts for additional covariates for DN analyses. This distinguishes from previous prominent approaches in DN analyses such as MDiNE and NetCoMi which do not feature a covariate adjustment of finding taxa that are differentially connected (DC, hereafter) between individuals with different clinical and phenotypic characteristics. SOHPIE with a vignette is available on CRAN repository https://CRAN.R-project.org/package=SOHPIE and published under General Public License (GPL) version 3 license.
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