Abstract
A computer software program that enables a user to predict any of several toxicity endpoints based on the structure of a chemical is now available. First release of the software, called Topkat, was made this month by Health Designs Inc. (HDI), Rochester. Topkat operates on an IBM PC/AT or fully compatible computer. It is available with any of several endpoints: rat oral LD 50 , mutagenicity (by the Ames test), carcinogenicity, teratogenicity, and rabbit skin irritation (Draize) and rabbit eye irritation. HDI displayed the software last month in Denver at the exposition held in conjunction with the national meeting of the American Chemical Society. The idea of the software models, says HDI president Kurt Enslein, is not to replace animal assays or in-vitro assays. Rather the models would help a researcher make an estimate of an untested chemical while it is still at the development stage to determine whether the chemical should be tested in animals. ...
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