Software package for planning fractionated schemes of irradiation of malignant tumors using local tuning of parameters of mathematical models

Abstract

1. The method of local tuning of mathematical model parameters developed in our laboratory increases the accuracy of planning of the fractionated irradiation schemes using the TDF factor. The method provides more accurate calculation of the TDF factor. 2. The software package for planning the fractionated schemes of irradiation determines the main radiological parameters of the irradiation regime as a set of interrelated values for remote (long-distance), contact (short-distance), or combined modes of RT and for regular or irregular DF schemes. 3. The software package allows a radiologist to use clinical data accumulated during his practice for tuning parameters of the mathematical model and planning of the fractionated schemes of irradiation. 4. The method of local tuning of parameters can be applied to other mathematical models of DF (LQ, etc.) as it was applied to the TDF model, because none of these models take into account functioning of normal organs and tissues adjacent to the pathological focus. The developed method of local tuning of the mathematical model parameters allows the use of accumulated experience in RT for increasing the efficiency of RT planning. The method minimizes the inadequacy of the mathematical model used.