Abstract
The use of soft x-ray-emitting radioisotopes in cancer therapy offers many potential advantages. Sixty-day iodine 125 and 9.7-day cesium 131 are particularly promising because of their “un-contaminated” monoenergetic x-ray emission of approximately 30 keV. Numerous advantages accrue as a result of the ease of shielding the 30 keV x rays, coupled with their useful range in tissue. Soft x-ray “seeds” containing I125 and Cs131 have been fabricated for use in brachytherapy. Dosimetry studies have shown that standard distribution rules normally used for radium or radon implants will apply equally well to implants of these “seeds” with the added advantages of more rapid fall-off beyond the implant. The tissue dose distribution in the first 1.5 cm from such a “seed” was found to be comparable to that from radium, while at distances beyond 5 cm the fall-off was significantly greater due to increased tissue absorption. Experience gained from their use in animal studies has demonstrated their ease of handling and p...
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