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Abstract
We report on the use of soft UV nanoimprint lithography (UV-NIL) for the development of reproducible, millimeter-sized, and sensitive substrates for SERS detection. The used geometry for plasmonic nanostructures is the cylinder. Gold nanocylinders (GNCs) showed to be very sensitive and specific sensing surfaces. Indeed, we demonstrated that less than 4 ×106 avidin molecules were detected and contributed to the surface-enhanced Raman scattering (SERS) signal. Thus, the soft UV-NIL technique allows to obtain quickly very sensitive substrates for SERS biosensing on surfaces of 1 mm 2.
Highlights
Surface-enhanced Raman scattering (SERS) technique was shown to be a very effective analytical tool for the detection and identification of molecules, thanks to its high sensitivity [1,2]
The SERS enhancement is due to the localized surface plasmon resonance (LSPR) of the metallic nanostructure
Gold nanocylinder fabrication Firstly, the imprint process is realized in the AMONIL, which is deposited on a PMMA resist
Summary
Surface-enhanced Raman scattering (SERS) technique was shown to be a very effective analytical tool for the detection and identification of molecules, thanks to its high sensitivity [1,2]. It has been widely used for ultrasensitive chemical analysis down to the single molecule sensitivity. The facts that SERS gives a specific fingerprint of a molecule and is sensitive to very small molecules make it a good candidate for application in the fields of chemical and biological sensors. The SERS enhancement is due to the localized surface plasmon resonance (LSPR) of the metallic nanostructure. We have discussed the necessity to optimize the size of
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