Abstract
Ameloblastoma is an odontogenic tumor of high frequency and usually occurs as an intraosseous growth. Ameloblastomas frequently recur, sometimes undergoing malignant transformation. These tumors are usually characterized as being multilocular, of the follicular type histopathologically, and invading strongly at the border region of the tumor. More than 10% p53-positive tumor cells give a prognostic indication for a tendency to recur. A recurrent ameloblastoma usually occurs in the intraosseous region near the site of the original lesion. In very rare cases, a recurrent tumor proliferates distantly from the original site in the soft tissue only. We report a rare case of recurrent ameloblastoma in the buccal mucosa with a mucocele that originated from the small salivary glands after the extirpation of an intraosseous (mandibular) ameloblastoma. We also performed a p53 immunohistochemical study of this recurrent tumor.
Highlights
Ameloblastoma is a benign odontogenic tumor that almost always occurs in the intraosseous region and has various histological forms
We report a rare case of recurrent ameloblastoma in the buccal mucosa with a mucocele that originated from the small salivary glands after the extirpation of an intraosseous ameloblastoma
We examined clinically and histopathologically a rare case in which ameloblastoma recurred in the buccal mucosa after the extirpation of an intraosseous ameloblastoma
Summary
Ameloblastoma is a benign odontogenic tumor that almost always occurs in the intraosseous region and has various histological forms. The follicular type is more likely to recur than the plexiform type in the solid/multicystic type [1] [2] The p53 gene is one of the tumor suppressor genes, and its expression or mutation has been examined in tumors such as oral squamous cell carcinoma or leukoplakia. It has been studied in odontogenic tumors including ameloblastoma [15]-[23]. We examined p53 expression in this recurrent tumor immunohistochemically
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