Soft Tissue Leiomyosarcoma

Abstract

A woman in her seventh decade of life underwent wide excision of a proximal thigh high-grade leiomyosarcoma after neoadjuvant radiation therapy. Which of the following statements is most accurate?a.Leiomyosarcomas are more common in children than in adultsb.Leiomyosarcomas occur more commonly in bone than in soft tissuec.Leiomyosarcomas most commonly occur as postradiation sarcomasd.The majority of soft tissue leiomyosarcomas do not have consistent recurrent genetic aberrations Answer: d. The majority of soft tissue leiomyosarcomas do not have consistent recurrent genetic aberrations Leiomyosarcoma comprises approximately 10% to 15% of limb sarcomas.1Evans H.L. Shipley J. Leiomyosarcoma.in: Fletcher C.D.M. Unni K.K. Mertens F. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press, Lyon, France2002: 131-134Google Scholar Leiomyosarcomas are more common in adults than in children, and retroperitoneal and inferior vena cava leiomyosarcomas are more common in women than in men. Leiomyosarcomas usually do not occur as a postradiation type of sarcoma. Leiomyosarcomas can involve the retroperitoneum, can arise in large blood vessels, and can involve the nonretroperitoneal soft tissues, particularly involving the lower extremity.1Evans H.L. Shipley J. Leiomyosarcoma.in: Fletcher C.D.M. Unni K.K. Mertens F. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press, Lyon, France2002: 131-134Google Scholar